We have seen quite a few Twitter clients and most of them are Adobe Air based application and Saezuri is no difference. Saezuri is another Twitter client based on Air platform and has some good feature and a decent interface. It uses the OAuth method, so you do not have to provide the username and password of Twitter account. It also has in build support from URL shortening and also adding images to Twitpic directly from the interface.
The setting page has few themes to customize the look of the application. You can set the update time for Twitter updates from the settings menu. There is provision to reply and retweet a message. Apart from this, it also has conversation type view where in you can see replies from a particular user in conversation style.